Hi Danny,
Now we have a situation where when I got to www.site.co.uk/webmail I simply get a directory listing of what is in /usr/share/roundcubemail instead of the login page I used to get.
The new Apache config doesn't seem to have any obvious issues with it, everything else loads fine, there are no errors logged at all.
could you post the contents of your apache vhost or if not used default site?
Regards, Thomas