When using PHP4 and setting $rcmail_config['db_persistent'] = TRUE; RC doesn't use persistent connetions. Here's the patch:
$ svn diff program/include/rcube_db.inc Index: program/include/rcube_db.inc =================================================================== --- program/include/rcube_db.inc (revision 259) +++ program/include/rcube_db.inc (working copy) @@ -80,7 +80,7 @@ */ function rcube_db($db_dsnw, $db_dsnr='', $pconn=false) {